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Please Write out the mechanism for the multistep synthesis below
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- Circle the correct answer in each sentence. Projection 1 is a (boat ; fischer ; haworth ; sawhorse) projection. Projection 2 is a (boat ; fischer ; haworth ; sawhorse) projection. This sugar is a (pentose ; hexose) and is a (aldose ; ketose). It is classified as a (simple ; complex) carbohydrate. This is the (L- ; D-) enantiomer of this sugar.Does this synthesis look right?drug synthesis from Gabriel synthesis
- 3. Atazanavir (structure below) is an orally delivered AIDS-drug which works as an inhibitor for the HIV aspartyl protease. OH Meo. .N. N. OMe `Ph Atazanavir i) Draw the high energy intermediate of an aspartyl protease-catalysed cleavage of the amide bond in the peptide R1-CO-NH-R?. ii) How well does Atazanavir follow the Lipinski's rules of five (log P 4.5)? IZ IZMake a synthesis for the transformation2. Each of 10 stereoisomeric sugar derivatives can be prepared via a multiple-step synthesis starting from either glucuronolactone 1D or its enantiomer 1L. (J. Org. Chem. 2012, 77, 7777-7792). 1L A. Draw the structure of 1L. 1D OH HO N OH HO OH sugar derivative B. How many stereoisomers of 1D are possible? C. Now consider the 10 stereoisomeric sugar derivatives. Draw the structures of the eight chiral products (as pairs of enantiomers) and the two achiral products (hint: meso).
- . Given your answer above, predict the product of the enzyme catalyzed transesterification reaction of cocaine with alcohol in the body, shown below. What chemical reaction(s) would occur if NaOH were used instead of NaHCO3 to react with cocaine in an effort to make crack cocaine? *Hint: Examine what other functional groups are present in cocaine.Match each synthesis of racemic leucine to what R has to be to complete it. Answers may be repeated. Picture in the middle pleaseWhy do you think both enzymes tested have the exact same optimal working temperature (i.e. temperature they work best at)?