1. You have a glucose molecule that is radiolabeled at carbon 5. a). Indicate which carbon(s) in pyruvate would be radiolabeled: b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the CH,OH H H. OH H но H3C- -coo он first isocitrate produced. CH2 HC -coo HO-CH čoo c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this turn of the TCA cycle.: Coo CH2
1. You have a glucose molecule that is radiolabeled at carbon 5. a). Indicate which carbon(s) in pyruvate would be radiolabeled: b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the CH,OH H H. OH H но H3C- -coo он first isocitrate produced. CH2 HC -coo HO-CH čoo c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this turn of the TCA cycle.: Coo CH2
Chemistry & Chemical Reactivity
10th Edition
ISBN:9781337399074
Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Chapter24: Biochemistry
Section: Chapter Questions
Problem 34GQ: The first step of the metabolic process known as glycolysis is the conversion of glucose to glucose-...
Related questions
Concept explainers
Organic Chemistry of Metabolic Pathways
Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.
Glucogenesis
Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general definition for glucogenesis or gluconeogenesis is as follows,
Question
![1. You have a glucose molecule that is radiolabeled at carbon 5.
a). Indicate which carbon(s) in pyruvate would be radiolabeled:
b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the
CH,OH
H
H.
OH H
но
H3C-
-coo
он
first isocitrate produced.
ÇoO
CH2
HÇ
-Co
HO-CH
c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this
turn of the TCA cycle.:
čoo
Coo
CH2
d). What turn of the TCA cycle would label start to be lost as CO; (1 turn has been completed) ?
e). Which carbon in pyruvate would have been labeled to give you the labeling pattern in part c, if that pyruvate
went through PDH and the TCA cycle, instead of pyruvate carboxylase.
H3C
-co
f). How is the label in part c physically distributed on actual oxaloacetate molecules?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F39285511-942f-4a28-a1ed-1df0a2f8d6cb%2F06e73a55-2e16-4c87-8cc2-7452741712bb%2Fvprsf65_processed.jpeg&w=3840&q=75)
Transcribed Image Text:1. You have a glucose molecule that is radiolabeled at carbon 5.
a). Indicate which carbon(s) in pyruvate would be radiolabeled:
b). If pyruvate is converted to oxaloacetate through pyruvate carboxylase, indicate the labeling pattern on the
CH,OH
H
H.
OH H
но
H3C-
-coo
он
first isocitrate produced.
ÇoO
CH2
HÇ
-Co
HO-CH
c). Indicate the labeling pattern and distribution in oxaloacetate at the end of this
turn of the TCA cycle.:
čoo
Coo
CH2
d). What turn of the TCA cycle would label start to be lost as CO; (1 turn has been completed) ?
e). Which carbon in pyruvate would have been labeled to give you the labeling pattern in part c, if that pyruvate
went through PDH and the TCA cycle, instead of pyruvate carboxylase.
H3C
-co
f). How is the label in part c physically distributed on actual oxaloacetate molecules?
Expert Solution
![](/static/compass_v2/shared-icons/check-mark.png)
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps with 1 images
![Blurred answer](/static/compass_v2/solution-images/blurred-answer.jpg)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
![Chemistry & Chemical Reactivity](https://www.bartleby.com/isbn_cover_images/9781337399074/9781337399074_smallCoverImage.gif)
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781337399074
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
![Chemistry & Chemical Reactivity](https://www.bartleby.com/isbn_cover_images/9781133949640/9781133949640_smallCoverImage.gif)
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781133949640
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
![Organic And Biological Chemistry](https://www.bartleby.com/isbn_cover_images/9781305081079/9781305081079_smallCoverImage.gif)
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,
![Chemistry & Chemical Reactivity](https://www.bartleby.com/isbn_cover_images/9781337399074/9781337399074_smallCoverImage.gif)
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781337399074
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
![Chemistry & Chemical Reactivity](https://www.bartleby.com/isbn_cover_images/9781133949640/9781133949640_smallCoverImage.gif)
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781133949640
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
![Organic And Biological Chemistry](https://www.bartleby.com/isbn_cover_images/9781305081079/9781305081079_smallCoverImage.gif)
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,
![General, Organic, and Biological Chemistry](https://www.bartleby.com/isbn_cover_images/9781285853918/9781285853918_smallCoverImage.gif)
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
![Introduction to General, Organic and Biochemistry](https://www.bartleby.com/isbn_cover_images/9781285869759/9781285869759_smallCoverImage.gif)
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
![Chemistry for Today: General, Organic, and Bioche…](https://www.bartleby.com/isbn_cover_images/9781305960060/9781305960060_smallCoverImage.gif)
Chemistry for Today: General, Organic, and Bioche…
Chemistry
ISBN:
9781305960060
Author:
Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:
Cengage Learning