1. Acetyl-CoA labeled with 14C in both of its acetatecarbon atoms is incubated with unlabeled oxaloacetatand a crude tissue preparation capable of carrying outthe reactions of the citric acid cycle. After one turn ofthe cycle, oxaloacetate would have ¹4C in:A. all four carbon atoms.B.no pattern that is predictable from the informationprovided.c.none of its carbon atoms.D.the keto carbon and one of the carboxyl carbons.E. the two carboxyl carbons.

The citric acid cycle, also called as the Tricarboxylic acid (TCA) cycle is the central metabolic…

Answered: 1. Acetyl-CoA labeled with ¹4C in both…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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A patient who has been drinking large amounts of alcohol for long periods of time shows thefollowing symptoms: apathy, loss of memory, and a rhythmical to-and-fro motion of the eyeballs.Which of the following reactions are most likely to be affected in the patient? A. Conversation of pyruvate to acetyl-CoA B. Conversation of a-ketoglutarate to succinyl-CoA C. Both A and B D. Neither A nor B
Characterize, in terms of number of carbon atomspresent, each of the following citric acid cycle changesas (1) a C4 to C4 change, (2) a C4 to C6 change, (3) a C5to C4 change, or (4) a C6 to C5 change.a. Oxaloacetate to citrateb. a-Ketoglutarate to succinyl CoAc. Fumarate to malated. Succinyl CoA to succinate
Consider the docosanoic acid, C21H43CO2H a. Label the a and B carbons b. Draw the acyl CoA derived from this fatty acid c. How many acetyl CoA molecules are formed by complete B-oxidation? d. How many cycles of B-oxidation are needed for complete oxidation? e. How many molecules of ATP are formed from the complete catabolism of this fatty acid?
1. Using your own diagram, illustrate the reactions that take place within thepyruvate dehydrogenase complex (including all enzymes and coenzymes) anddiscuss the role of the enzymes involved. 2. Graphically represent all the regulatory mechanisms of the citric acid cycle and discuss their effect on the cycle.
When acetyl-CoA containing radioactively labeled carbon atoms is fed to cells, the CO, produced is not initially radioactive. However, molecules of citrate and oxaloacetate are radioactive. Only after some time has passed will radioactive CO2 be released. What is the best explanation for this observation?
Which of the following statements about the transport of citrate for fatty acid synthesis are false? 1. Citrate is able to cross the inner mitochondrial membrane through the citrate transporter integral membrane protein. II. In the cytoplasm citrate synthase catalyzes the production of acetyl- CoA and oxaloacetate III. After lysis of citrate the oxaloacetate is oxidized to malate by a cytoplasmic form of malate dehydrogenase. II and III only Fonly II only Ill only I and II only
If 14CO2 (radioactive carbon) were incorporated into the TCA cycle via the Pyruvate Carboxylase reaction which of the following molecules would contain radioactive carbon? a. Oxaloacetate b. Citric Acid c. Isocitrate d. Alpha-ketoglutarate e. Succinyl-CoA f .Succinate g. Fumarate h. Malate
Fatty acids are oxidized by acyl COA dehydrogenase. Branched fatty acids, containing a methyl group at beta carbons cannot be oxidized by this enzyme. How does the oxidation of such branched fatty acids take place? Explain with all set of reactions and enzymes involved.. give necessary detail.. avoid cpy righting
Which of the following statements is true about the citric acid cycle a. The Citric Acid Cycle is an 8-step cycle that produces the most electron carrier molecules throughout the process of cellular respiration. b. In Citric Acid Cycle, both the acetyl group and coenzyme A of Acetyl CoA are combined to oxaloacetate. c. In Citric Acid Cycle, glucose is only partially broken down and there are still remnants of glucose after this process. d. The ATP produced during this process is via oxidative phosphorylation
3) Indicate the order in which the metabolites in citric acid cycle are produced; acetyl CoA as 1 and oxaloacetate as 9. Metabolites in Citric Acid Cycle Order Enzyme involved in the formation of the metabolite Acetyl CoA 1 Oxaloacetate 9. Succinyl SCOA Fumarate Malate Citrate Succinate a-Ketoglutarate Isocitrate
In the context of fatty acid oxidation to acetyl CoA, indicate whether each of the following substances is involved in (1) fatty acid activation, (2) fatty acid trans-port, or (3) b-oxidation pathway. More than one choice may be correct in a given situation. a. AMp b. FAD c. Acyl CoA d. H2O
The carbon skeletons of many amino acids can be used to replenish the intermediates of the citric acid cycle. Select one: True O False Which of the following compound is a positive allosteric modifier of the enzyme pyruvate carboxylase? Select one: a. Biotin O b. Oxaloacetate O c. Fructose-6-P O d. ATP Oe. Acetyl-CoA Which of the following compounds serve as a primary link between the TCA cycle and the urea cycle? Select one: O a. succinate b. fumarate O c. oxaloacetate O d. malate O e. citrate A specific inhibitor for succinate dehydrogenase is: Select one: O a. Citrate b Malonate O c. Arsenite O d. Fluoride O e. Cyanide

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