1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? ROH+ NaHRONa+ + H₂ b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? c) Why is NaH rather than NaOH used in this reaction?
1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? ROH+ NaHRONa+ + H₂ b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? c) Why is NaH rather than NaOH used in this reaction?
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter13: Substitution
Section: Chapter Questions
Problem 13E
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