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Dec 6, 2023
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The Case of the Murdered Midwife
Part I: The Investigation
It’s your first day shadowing a detective, and already it’s been interesting…if you can
call the murder of a young woman interesting. You’ve been trying to detach yourself
by reading the file, but you have interviews later this morning and you’re nervous.
Going back to the file, you jot down some notes on what you know so far.
Meleea was a 35-year-old nurse midwife with over ten years’ experience delivering
babies both in hospitals, as well as in homes when risk for complications were low.
She was healthy; her only medical condition was an allergy to bee stings. The body
was discovered by her boyfriend when he came over for a planned dinner. The
dinner – spaghetti – was laid out, but no cooking had begun. There was also a plate
of cupcakes, with a bite out of only one of them. The boyfriend said Meleea had not
mentioned feeling unwell when they spoke earlier in the day. She was, however,
tired, and understandably upset about a long birth she had assisted with where a
mother had died in childbirth.
The medical examiner did not have results yet, so you sketch out some questions
you have for the interviewees.
1.
Who would you interview, and what would you ask?
BOYFRIEND: where were you when Meleea was home? Who made the
cupcakes? When did you last hear from her? Have you been fighting lately?
COWORKERS OR FRIENDS: how was maleea at work? Has she been acting
any different? Were there any other love interests in her life? Did she seem
happy? Who would want her dead?
FAMILY: What was your relationship with her? Did she say she had any
concerns about someone? Has she mentioned someone making her feel
weird in the past?
2.
Do you have any hypotheses about what happened to Meleea? Write at least
one or two possibilities.
I am curious on if she somehow choked on the cupcake she bit, maybe went
down the wrong way and she couldn’t get water or cough it up alone. I am
also wondering if there was an unknown food allergy that might’ve caused
her death.
Part II: The Medical Examiner’s Report
You now have the medical examiner’s (ME) report. The ME believes she died of
asphyxiation. You read that there were no marks on the body, including bee stings.
She was healthy, but tissue analysis showed some bizarre results. There was tissue
death, but not only that, microscopic analysis showed mitochondrial damage. In
addition, there were high levels of oxygen in all tissues examined.
1.
Based on the above, what cellular process might have been interrupted?
Support your answer with the information above and knowledge gained in
this module. Cite sources using APA Style.
The cellular process that would’ve been affected is cellular respiration, this will
cause the cells to not be able to function due to the blockage of oxygen.
2.
Are there any conflicting pieces of information in the above? If so, what are
they?
How could she have died from asphyxiation if she had oxygen in the tissues. If there
was lack of oxygen, the tissues would be dead and the cells would’ve not been able
to function properly resulting in death.
Part III: Analysis of Metabolites
The ME’s report also has a note at the end. She suspects poisoning based on the
below results.
Metabolite
Level Compared to Normal
(High, Normal, or Low)
Oxygen
High
NADH
High
NAD+
Low
Pyruvate
Normal
Glucose
Normal
Acetyl CoA
Normal
ATP
Low
ADP
High
1.
What is the role of each of the above metabolites in cellular respiration?
OXYGEN: Has high energy electrons after they get taken from glucose
NADH: carrier derived from Vitamin b3 and Niacin.
NAD+:Carrier that has the oxidized form and can accept electrons
PYRUVATE: end product of glycolysis
GLUCOSE: used to make energy
ACETYL COA: carries carbon atoms from the acetyl group to the
Tca cycle and helps with energy
ATP: energy currency for cells and stores energy
ADP: formed when the phosphate groups of atp are lost, its converted to atp.
2.
Which of the above are abnormal? Which are normal?
Its abnormal for high levels of oxygen, NADH, ADP, low is NAD+ and ATP. Normal
is pyruvate, glucose, and acetyl coa
3.
Based on your answers to the first two questions, what part of cellular
respiration do you believe was interrupted?
I think it was the citric acid cycle that was interrupted due to the ATP being low
which means that none of the other functions were not happening. The levels are
high due to the oxidative stage and low because it needs to remove electrons
causing the citric acid cycle to fail.
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