Kenneth G. Wilson (1923). The Columbia Guide to Standard American English. 1993.
downer, upper (nn.)
These two are slang and may already be somewhat faded. A downer is a drug or other depressant and refers particularly to a barbiturate or similar drug. The figurative use is also slang and is widely encountered; it means any experience or news that depresses: Last nights meeting was a real downer. An upper is also slang, with exactly the opposite meaning: drugs or other stimulants that exhilarate, such as amphetamines, are uppers, and the figurative sense could be applied to any cheering experience. There is also an older, Standard sense of upper, meaning an upper berth in a Pullman railroad car or other travel sleeping accommodation: We each had an upper on the trip to Cleveland. (The lower berth is called a lower, not a downer.) The idiom on ones uppers means that the soles of ones shoes are worn through, so that whats left is just the upper parts of them, the uppers; hence, Hes on his uppers means hes down and out.